Clinicopathological features of adenocarcinoma of the esophagogastric junction        SUN Yu, LI Ji-you. Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing100142, China
Corresponding author: SUN Yu, E-mail: sunyu_bch@163.com
Abstract    Gastric and esophageal cancers are among the leading causes of cancer-related death worldwidely. By contrast with the decreasing prevalence of gastric cancer, incidence and prevalence of adenocarcinoma of the esophagogastric junction (AEG) are rising rapidly in developed countries. Many discrepancies exist in the published work about the causes, diagnostic criteria and clinicopathological features of AEG. Histogenesis of most AEG is related with Barrett’s esophagus. The pathogenic process includes intestinal metaplasia, low grade dysplasia, high grade dysplasia and adenocarcinoma.