Adenocarcinoma of the esophagogastric junction: epidemic trends, causes, prevention and therapy      CHEN Zhi-feng. Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Abstract    Population epidemiology analysis of esophageal cancer for the high risk region in China finds that: incidence of esophageal squamous cell carcinoma has decreased and that of adenocarcinoma of the esophagogastric junction(AEG) has increased significantly. European and American scholars believe that obesity and stomach-esophageal reflux disease are independent risk factors of the two types of cancer. In the high risk region of esophageal cancer in China, the heritability is (29.67±4.32)% and the segregation ratio is 0.181, 95% CI (0.15~0.21). Esophageal cancer belongs to multi-gene genetic disease. According to the evolution of the pathological mechanism of gastric cardia  adenocarcinoma and the WHO's clinical treatment principles, cardiac severe atypical hyperplasia were mainly endoscopic resection in the high risk region in China. Paying attention to the intervention of atrophic gastritis or active gastritis may be the realistic measures to reduce intestinal metaplasia and the incidence of AEG.