Diagnosis and therapy of myopathy and peripheral neuropathy complicated with liver transplant recipients who administered telbivudine:an analysis of 3 cases        WANG Gen-shu*, LI Min-ru, LI Xue-jun, et al. *Organ Transplantation Institute, Sun Yat-sen University; Liver Transplantation Center, Affiliated Third Hospital, Sun Yat-sen Universiy, Guangzhou 510630, China
Corresponding author: CHEN Gui-hua,E-mail: chgh1955@263.net
Abstract    Objective    To investigate the diagnosis and therapy of myopathy(MP) and peripheral neuropathy(PNP) complicated with liver transplant recipients who administered telbivudine. Methods    The clinic featuers and treatments of MP and PNP after administering telbivudine in three patients who received liver transplantation from June 2008 to June 2009 in  Affiliated Third Hospital of Sun Yat-sen University were investigated retrospectively. Results    The incidence of MP and PNP among the liver transplant recipients who administered telbivudine was 11.5% (3/26). The average time from taking telbivuding to appearing symptoms of MP and PNP was 11.7 months. The average time from appearing symptoms to diagnosis was 10.7 months. The manifestation disappeared 3 months after treatment. Conclusion Liver transplant recipients who administer telbivudine and tacrolimus meantime have a relatively high incidence of MP and PNP. In order to early diagnose and treat MP and PNP, attention should be paid to observe related manifestations of MP and PNP and monitor serum creatine kinase and myoglobin.