Laparoscopic versus open surgery in treating serosa-invaded colorectal cancer: a comparative study of prognosis        LIU Feng, YU Jiang, LIANG Yao-ze, et al. Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
Corresponding author:LI Guo-xin, E-mail:gzliguoxin@163.com
Abstract    Objective    To evaluate the prognosis between laparoscopic and open approach in treatment of serosa-invaded colorectal cancer. Methods    The clinicopathological and follow-up data of patients with serosa-invaded colorectal cancer in the Nan fang Hospital of Southern Medical University from Jun. 2003 to Jun. 2007 were analyzed retrospectively. Recurrence and survival rates were compared respectively between two groups. Results There were no statistically significant differences of baseline data and follow up period between laparoscopic surgery (LS) and open surgery (OS) groups. No significant differences were observed in overall mortality (20.7 % in LS and 28.9 % in OS, P= 0.234) and cancer-related mortality (17.2% in LS and 26.8 % in OS, P =0.105). The difference of recurrence rate (12.1 % in LS and 26.8 % in OS, P= 0.024) between the two groups was significant. As survival analysis showed, there were no significant differences in cumulative overall survival(P=0.159) and cumulative cancer-related survival(P=0.083). The difference of recurrence-free rates between the two groups was  significant(P=0.024). Conclusion    The recurrence rate of LS was fewer obviously than OS, so the laparoscopic surgery can obtain some superior outcomes compared with open surgery for serosa-invaded colorectal cancer.