Gastrointestinal stromal tumors and translational medicine        ZHANG Xin-hua, HE Yu-long, ZHAN Wen-hua. Department of Gastrointestinal and Pancreatic Surgery, the First Affiliated Hospital of Sun Yat-sen Univercity, Guangzhou 510080, China
Corresponding author: ZHAN Wen-hua, E-mail: wenhuazhan@medmail.com.cn
Abstract    Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Gain-of-function mutations on tyrosine kinase receptor are the keys of oncogenesis in GIST, which become the target of therapy, as well as the mechanism of drug resistance. A decade of progress in clinical management of GIST becomes a model of   translational medicine research, which advocates rapid conversion from the laboratory achievement to clinical application.