Further discussion on several concerns with diagnosis and treatment of early breast cancer        LIU Yin-hua, XU Ling. Department of Surgery, Peking University First Hospital，Beijing100034，China
Corresponding author: LIU Yin-hua,E-mail: liuyinhua@medmail.com.cn
Abstract    In June 2011 the Ministry of Health of the People’s Republic of China published “the Standard Diagnosis and Treatment of Breast Cancer”. It is not only beneficial to improve the quality of the breast cancer treatment, but also provide the criteria of medical behavior. Individualized treatment is based on accurate diagnosis in priority and followed by standard therapy. In March 2011 the International St. Gallen Consensus on the Treatment of Early Breast Cancer recommended that the immunohistochemical definition of ER, PR, the detection of overexpression and/or amplification of the HER-2 oncogene, and Ki67 labeling index were used to identify tumor subtypes. The definition of biological subtypes means that the knowledge about breast cancer developed from the TNM stage based on anatomy and histology grade based on histopathology to subtypes based on molecular level. And systemic treatment recommendations for subtypes were useful for the evidence based individualized treatment.