Clinicopathologic features of gastrointestinal stromal tumors and extragastrointestinal stromal tumors : an analysis of 216 cases        SHEN Wang*, WANG Xin-yun, ZHENG Hai-yan, et al. *Department of Seven-year Clinical Medicine, Tianjin Medical University, Tianjin 300070, China
Corresponding author: WANG Xin-yun, E-mail:michelle0096@sina.com.cn
Abstract    Objective    To investigate the features of clinicopathology and immunohistochemistry and the diagnostic criteria of gastrointestinal stromal tumor（GIST）and extragastrointestinal stromal tumor（EGIST）. Methods    The case data of 216 patients diagnosed as GIST and EGIST admitted between 2000 and 2009 in Tianjin Medical University General Hospital (175 patients) and the Second Hospital (41 patients) were analyzed retrospectively. Results    In the 216 patients, 112 patients were male and 104 patients were female. The ratio of male to female was 1.077:1. The range in age was from 15 to 91 years old. The median age was 58 years old. The tumors originated from the gastrointestinal tract were in 182 patients, and most of them were located in the stomach. The tumors originated from the extragastrointestinal tract were in 34 patients, and most of them were located in the mesenterium. The range in the diameter of tumors was from 0.8cm to 30.0cm. Tumors were composed of spindle cells and epithelioid cells. Cells arranged in interlacing, whorled and nesting. CD117-test was positive in 214 cases. Clinical manifestations were alimentary tract hemorrhage, abdominal pain, abdominal mass, intestinal obstruction and so on. Conclusion    GISTs are more than EGISTs. Medium risk and high risk are predominant in the gastrointestinal tract, and high risk is predominant in the extragastrointestinal tract. Wide excision is the first choice in the clinical treatment principle.