Clinical efficacy and quality of life of pylorus-preserving gastrectomy for early gastric cancer: a Meta-analysis      LIANG Ji-wang, SONG Yong-xi, SUN Jing-xu, et al. Department of Surgical Oncology and General Surgery, the First Hospital of China Medical University, Shenyang 110001, China.
Corresponding author: WANG Zhen-ning, E-mail：josieon826@yahoo.com.cn
Abstract    Objective    To assess the clinical efficacy and postoperative quality of life of pylorus-preserving gastrectomy(PPG) for early gastric cancer. Methods    Literature search was performed in PubMed, Wiley Online Library, Chinese Biomedical Database(CBM), CNKI, VIP and Wanfang to identify clinical randomized controlled trails on PPG and conventional distal gastrectomy (CDG) for early gastric cancer published between January 1995 and November 2010.RevMan 5.0 software was used for statistical analysis. Results    A total of 13 studies involving 1011 patients were included. Meta-analysis showed that compared with PPG group, early dumping syndrome, gastritis were more common in CDG group. Nutritional status and the average relative body weight in PPG group were better than those in CDG group significantly. However, there were no significant differences between the two groups in complications, gallstones and reflux esophagitis. Conclusion    PPG is safe and effective for the treatment of patients with early gastric cancer, which may have a better postoperative quality of life. Due to the poor quality and small sample size of included trials, more well-designed randomized controlled trials should be performed.