胃癌AJCC分期第6版与第7版的差异及其对预后评估的分析与比较

Chinese Journal of Practical Surgery ›› 2011, Vol. 31 ›› Issue (08) : 675-680.

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Chinese Journal of Practical Surgery ›› 2011, Vol. 31 ›› Issue (08) : 675-680.
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Abstract

The analysis of gastric cancer staging AJCC 6th ed. and 7th ed.        SHAN Fei, LI Zi-yu, BU Zhao-de, et al. Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Gastrointestinal Surgery, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China
Corresponding author:JI Jia-fu, E-mail: jiafuj@hotmail.com
Abstract    Objective    To evaluate clinical value of the 7thed gastric cancer staging AJCC by comparing with the 6thed.  Methods    It performed a retrospective analysis of 922 gastric cancer patients with complete clinical data. The patients had all been treated in Beijing Cancer Hospital from Sep. 1995 to Dec. 2007. The prognostic differences between the 6th ed. gastric cancer staging AJCC and the 7th ed. were analyzed by the Kaplan-Meier method and compared by the log-rank test. The multivariate analysis used the Cox stepwise logistic regression.  Results    The 7th ed.witnessed considerable adjustments in T staging and N staging which showed better performance in prognosis of gastric cancer patients. In a multivariate Cox model, patients who had earlier M staging , earlier 7th ed. N staging, earlier 6th ed. TNM staging and lymph node dissection were associated with better survival.  Conclusion    T staging and N staging of 7th ed. show better performance, but the 7th TNM staging has not been proven to be superior to the 6th  ed., and the further study should be carried out to verification.

Key words

gastric cancer / TNM staging

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