Gallbladder stones and gallbladder carcinoma        JIANG Zhao-yan, HAN Tian-quan, ZHANG Sheng-dao. Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery,Shanghai 200025, China
Corresponding author: HAN Tian-quan, E-mail: digsurgrj@yahoo.com.cn
Abstract    Gallbladder carcinoma is difficult to be early diagnosed leading to poor prognosis. The pathogenesis of gallbladder carcinoma is not clear. Cholelithiasis is shown to be associated with gallbladder carcinoma. Mechanical irritation, bacterial infection, xenobiotic in the bile may induce the carcinogenesis of gallbladder epithelium. Several risk genes associated with gallstone disease are also shown to be related with gallbladder carcinoma. Proper treatment of gallstone disease may provide a protective role in prevention of gallbladder carcinoma.