Clinical application of ultrasound-guided core needle biopsy for breast lesions        LI Jin-ping*, LI Juan , WU Li-gang,et al.*Chongqing Medical University, Chongqing 400016, China
Corresponding author ：LIU Qi-lun, E-mail：liuql6311@hotmail.com
Abstract    Objective    To evaluate the clinical value of ultrasound-guided core needle biopsy (US-CNB) as a preoperative diagnostic modality for breast lesions. Methods    Data were collected prospectively from August 2007 to May 2009 for 115 ultrasound-guided core needle biopsy that were followed by excisional breast procedure (EP) within 1 week at our hospital. The histopathological diagnosis on ultrasound-guided core needle biopsy was then compared with the findings of the excisional biopsy. Results    Out of the total 115 cases, US-CNB showed 81 as invasive ductal carcinoma, three invasive lobular carcinoma, two ductal carcinoma in situ，two atypical ductal hyperplasia and 26 benign disease. The principle histology identified at CNB was confirmed at EP for 93.9% of the lesions, generating a kappa value of 0.891(P＜0.01). The sensitivity for malignancy with CNB was 95.6% and the specificity was 100%. The false negative rate was 4.39% and the false positive rate was 0. Overall, our results indicate moderate agreement between the principal histology identified at USB relative to that identified at EP. Conclusions    Ultrasound-guided core breast biopsy is a satisfactory procedure for the histopathological diagnosis of breast lesions. Any unsatisfactory, suspicious or atypical change on US-CNB should be followed by an open biopsy.