Catheter-directed thrombolysis for acute lower limb deep venous thrombosis        HUANG Xiao-zhong, LIANG Wei，XUE Guan-hua, et al.  Department of Vascular Surgery, Renji Hospital, Affiliated Shanghai Jiaotong University School of Medical，Shanghai200001，China
Corresponding author： ZANG Ji-wei，E-mail：zhangjiwei001@sina.com  
Abstract    Objective    To evaluate the efficacy of catheter-directed thrombolysis in treatment of acute lower limb deep venous thrombosis(DVT). Method    217 patients with lower limb acute DVT underwent treatment by cathter-directed thrombolysis with urokinase (261.26±95.35)×104IU  continues infusion immediately. The venous patency score and the rate of patency were measured before and after lysis, improvement were observed by venograms. some patients were followed. Results     After lysis, the venous patency score was significant difference (P<0.01). The mean rate of venous patency improvent was （62.24±15.47）%. 153 patients were followed 6~28 monthes, average （13.75±7.63 ）monthes. The mean score of venous patency was also significant difference (P<0.01), the mean rate of venous patency improve to （68.37±17.54）%. The valve function preserved in 126 patients(82.35%). Conclusion    This initial experience suggest that catheter -directed thrombolysis with urokinase for treatment of acute lower limb DVT is safe and effective.