Effects of acute normovolemic hemodilution on coagulation and fibrinolysis in eldly patients undergoing hepatic carcinectomy        GUO Jian-rong*，YU Jun，DU Jin-man，et al．*Department of Anesthesiology，Lihuili Hospital，Medical College of Ningbo University，Ningbo 315040，China
Corresponding  author ：GUO Jian-rong，E-mail：jianrguo@126.com
Abstract    Objective    To observe the effects of acute normovolemic hemodilution (ANH) on coagulation and fibrinolysis on eldly patients undergoing hepatic carcinectomy．Methods    Thirty liver cancer patients (ASA ⅠorⅡ) over sixty years old performed hepatic carcinectomy from February 2007 to February 2008 at Lihuili Hospital，Medical College of Ningbo University were randomly divided into ANH group (groupA，n=15) and control group(group B，n=15)．Results    The perioperative blood loss was not significantly different between the two groups (P>0.05). The volume of allogeneic blood transfusion in ANH group was significantly less than that in control group [（350.0±70.7）mL vs.（457.0±181.3）mL, P<0.01]．Compared with before anesthesia induction，PT and APTT in both groups prolonged significantly at 30 minutes after ANH，but they all remained in normal range．TT and DD had no significant changes between the two groups．SFMC and F1+2 increased in both groups, but without statistical significance. PAC-1 and CD62P expressions of ANH group were significantly lower than before anesthesia induction（P<0.05）．Compared with group B，CD62P were significantly lower in ANH group after ANH．But there was no statistical significance between the two groups(P>0.05)．Conclusion    In elderly patients undergoing resection of liver cancer, ANH has no obvious impact on fibrinolysis and coagulation function. It could therefore be safe to reduce allogeneic blood transfusion largely．