Clinicopathologic diagnosis of mixed exocrine-endocrine carcinoma of the esophagogastric junction        WANG Zhan-dong*, WANG Yong-jun, YANG Jie, et al. *Department of  Pathology, Hebei University Fourth Hospital, Shijiazhuang 050011,China
Corresponding author：WANG Xiao-ling，E-mail：wangxiaoling5412@163.com
Abstract    Objective    To investigate the clinicopathological features of mixed exocrine-endocrine carcinoma (MEEC) of the esophagogastric junction. Methods    Seventeen cases of  MEEC were distinguished from 60 cases of cancer of the esophagogastric juntion by S-P immunohistochemical staining methods, with synaptophysin,chromogranin and neuron-specific enolase (NSE)  antibodies in March 2008 at Hebei University Fourth Hospital. Results    Seventeen cases of MEEC have differentiated four distinct tumors. The morphological types of the tumors were tublar adenocarcinoma，signet ring cell  carcinoma，poor differentiated adenocarcinoma and small cell carcinoma with neuroendocrine diffrentiation. Synaptophysin in 17 cases of mixed exocrine-endocrine carcinoma were positive, and 10 cases showed diffuse strong positive. Ten cases with chromogranin expression, and 11 cases with NSE expression, 5 cases expressed three antibodies. Conclusion    MEEC is a newly described entity, with only very few cases reported in the literature. More attention should be paid in the daily practice in order to differentiate the tumor from tublar adenocarcinoma, signet ring cell carcinoma and poor differentiated adenocarcinoma .The prognosis of  the tumor has not determined,which need more studied.