Adverse effects of tumor targeted therapies        CHEN Shan-shan，FENG Feng-yi. Chinese Academy of Medical Sciences Cancer Hospital, Peking Union Medical College,Beijing 100210, China
Corresponding  author：FENG Feng-yi ，E-mail：ffy43210@yahoo.com.cn
Abstract    Great advances have been achieved in the field of tumor targeted therapies in the last few years. Hypertension is a vascular endothelial growth factor inhibitor common side effects, and trastuzumab major adverse cardiac toxicity. Other adverse reactions are bleeding, delayed wound healing, gastrointestinal perforation, skin adverse reactions, hand-foot syndrome and mucositis, diarrhea, proteinuria. Thrombosis and reversible posterior leukoencephalopathy syndrome are rare but very serious. Early and rapid diagnosis, timely withdrawal are the keys to determine patient prognosis.