The related factors study of lymph node metastasis in 212 patients with early gastric cancer        PANG Tao, FANG Guo－en, LUO Tian－hang，et al. Department of General Surgery, Changhai Hospital, the Second Military Medical Universiry, Shanghai 200433, China 
Corresponding  author ：XUE Xu－chao, E-mail: xuexch@163.com
Abstract    Objective    To observe the relationship between clinicpathological and immunopathological features of early gastric cancer (EGC) and lymph node (LN) metastasis.  Methods    A retrospective study was performed on 212 EGC patients who had been treated in the Department of General Surgery of Changhai Hospital between January 2006 and December 2008. The influence of tumor size, differentiation, macroscopic type, depth of invasion as well as CAM5.2, P53, Ki?67 expression on LN metastasis were studied by t test, χ2 test and logistic regression analysis. Results    Tumor macroscopic type, size, depth of invasion, differentiation were positively related to LN metastasis with P value of 0.014, 0.001, 0.012, 0.006 respectively, and the correlation coefficient were 2.213, 1.779, 4.737, 4.15 respectively. The expression of P53, CAM5.2 were also positively related to LN metastasis, with P value and correlation coefficient were 0.001, 0.000 and 1.922, 3.632 respectively. Age, sex, tumor location, tumor number, P16, TopoⅡ, Ki?67 were not related to LN metastasis. Conclusion    LN metastasis in EGC is mainly correlated with tumor macroscopic type, size, depth of invasion, differentiation, etc. It could evaluate the micrometastasis on the basis of CAM5.2 and P53, which should be considered when a treatment was decided.