How to establish a high quality clinical surgical research LIU Lian-xin.Department of General Surgery, the First Affiliated Hospital of Harbin Medical University，Harbin150001,China Abstract Although the development of general surgery today is rapid, there are still many obstacles yet to be studied and solved. We should design ethics of clinical research to be retrospective on the basis of the past and the prospective practical work, also taking in account the scenarios of latest advancement from home and abroad, guided by the experience of others and experts. Clinical studies besides being deserving should be practical, scientific, feasible, and innovative. In addition, clinical studies should be using different research methods and statistical analysis techniques in the light of different research objectives to finally reveal the mechanisms of different diseases and assiduously tackle them.