Stereotactic guided mammotome biopsies in diagnosis of suspicious breast microcalcifications LEI Yu-tao*, HOU Kuan-yong, LIU Yi,et al.*General Suregery, Peking University Third Hospital, Beijing 100191，China Corresponding author：LEI Yu-tao，E-mail：leiyt@vip.sina.com Abstract Objective To evaluate the clinical application of stereotactic guided Mammotome biopsy in the diagnosis of breast microcalcifications. Methods During November, 2007 and December, 2008, we diagnosed and treated 21 patients with 29 untouched calcification lesions, aged 28 to 67 with an average of 46.6. Excision or biopsy of the lesions was performed using Mammotome biopsy under stereotactic guidance, and then all cases were followed up in 1-9 months. Results 29 lesions from 21 patients were excised with stereotactic guided Mammotome biopsy. 15 lesions completely removed appeared as clustered calcifications in diameter <1cm. 5 lesions in 4 patients were diagnosed as DCIS, the others were showed to be hyperplasia, in which 7 lesions appeared as fibrocystic hyperplasia, 3 lesions accompany with varying degrees of ductal epithelial hyperplasia, and 1 lesion with papilloma formation. 1 patient after operation appeared hematoma at the puncture site, which absorbed naturally after 2 weeks.. In the follow-up study, 4 patients undergoing mastectomy appeared without recurrence, and others show no signs of malignancy. Conclusion Stereotactic guided Mammotome biopsy is position fixed accurately and minimally invasive to breast surgery, especially suitable for breast microcalcification.