Treatment and prognosis of pseudomyxoma peritonei WANG Yao*，FANG Guo-en，ZHANG Jin, et al. *Department of General Surgery，Changhai Hospital of the Second Military Medical University，Shanghai 200433，China Corresponding author：FANG Guo-en，E-mail：wangyaoo1982@yahoo.cn Abstract Objective To summarize the experience of treating pseudomyxoma peritonei（PMP）and analyzed the prognosis. Methods A total of 42 patients with pseudomyxoma peritonei（PMP）treated in our hospital from 1990-2008 were analyzed retrospectively. OF the 42 patients , 21 underwent cytoreductive surgery(CRS group),19 underwent CRS and intraoperative peritoneal hyperthermia-chemotherapy(CRS＋IPHC group).The median follow-up period was 6.8 years（range，1～16 years）. Results There was no significant difference in 1-year survival rate between the CRS group and CRS＋IPHC group（P>0.05）.The 3，5-year survival rates were significant higher in CRS＋IPHC group than in CRS group, while the recurrence rate was in contrast（P<0.05）. Conclusions The using of CRS and IPHC might improve the survival rate of patients with PMP.