In regard to japanese gastric cancer treatment guidelines-the 3rd Edition HU Xiang. Department of General Surgery，the first Affiliated Hospital，Dalian Medical University，Dalian 116011，China Abstract The Japanese Gastric Cancer Association will issue a revised edition of gastric cancer treatment guidelines in Jan, 1st, 2010. Distinctive features of this revision are lymph node grading based on the removal effect, lymphadenectomy according to the D1/D2 dissection. Based on a high level evidence-based medicine, the Para-aortic lymph node dissection in D3 dissection was excluded in this edition. According to JCOG9912 and SPIRITS trials, neoadjuvant chemotherapy with CDDP and TS-1 has become a standard option in unresectable or recurrent gastric cancer. So the revised edition of gastric cancer treatment guidelines provided more advanced and scientific treatment programs.