Clinical assessment of resuscitation in septic shock GUAN Xiang-dong，CHEN Min-ying. Department of Intensive Care Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China Corresponding author: GUAN Xiang-dong, E-mail: carlg@163.net Abstracts The central role of septic shock is microcirculation disturbance. Major resuscitation goals for septic shock include restoration of adequate tissue perfusion and oxygen balance and normalization of cellular metabolism. Traditional endpoints of resuscitation, such as HR, BP, urine output, and skin perfusion are inadequate to evaluate the effect of resuscitation. Optimal resuscitation endpoints need to include hemodynamics status, tissue perfusion and oxygenation. The parameters in early goal-directed therapy including mean arterial pressure ≥65mmHg, central venous pressure 8～12mmHg, urine output ＞0.5mL/kg·h, ScvO2 ＞65% or SvO2＞70% become the popular parameters in clinical assessment.