The application of ultrasound guided vacuum assisted excision system in the diagnosis and treatment of breast disease XU Xiao-zhou, ZHANG BO-lin, WANG Xiang. Cancer Hospital, Chinese Academy of Medical Science, Beijing 100021, China Corresponding author: WANG Xiang, E-mail: Xiangw@vip.sina.com Abstract Objective To investigate the clinical value of ultrasound guided vacuum assisted excision on the diagnosis and treatment of breast lesions. Methods Ultrasound guided vacuum assisted excision was performed on 469 lesions from 416 patients between Dec 2006 to May 2008. Its value on diagnosis and treatment of breast lesions was analyzed retrospectively. Results Among them, there were 6 cases of invasive ductal carcinoma and 3 case of intraductal carcinoma(four cases of T0 stage and five cases of T1 stage) and 460 cases of benign lesions. All patients with breast cancer received additional radical operation and no histological underestimation was found. 2 cases of local recurrence among the benign lesions were found six month later and received another excision with the pathological diagnosis of fibroadenoma. No remnant lesion was found at the re-examination six months later. Incidence rate of postoperative complications was 1.2%. Conclusion Breast lesions with the maximum diameter from 5 to 28 millimeters could be resected completely by ultrasound guided vacuum assisted excision system and obtained the pathologic diagnosis. With the help of this method, we can find breast cancer in early stage suspected by ultrasound. In addition, benign disease could also be treated with a minimum wound. This technique has the characteristics of accurate, safe and small wound.