The compliance of implementing sepsis bundles and their effects on mortality of patients with severe sepsis or septic shock WU Jian-feng, CHEN Juan, OU Yang-bin, et al. Department of Surgical Intensive Care Unit, the First Affiliated Hospital of SUN Yat-sen University, Guangzhou 510080, China Corresponding author: GUAN Xiang-dong, E-mail: carlg@163.net Abstract Objective To evaluate the compliance of implementing sepsis bundles in the ICU and their effect on outcomes of patients with severe sepsis or septic shock. Methods In the prospective observational study, it took to applying sepsis bundle interventions for 6h, 24h in 122 consecutive patients with severe sepsis or septic shock admitted from January 2007 to December 2008 at the First Affiliated Hospital of Sun Yat-sen University. The compliance of performing sepsis bundles, ICU and 28-day mortality were recorded. Results The compliance rate of controlling glucose and EGDT was low (both＜70%) because both had defects and difficulty in implementation. Compliance with the 6-hour bundle was obtained in 75 (61.5%) of 122 patients; those patients had a lower 28-day mortality rate (22.7% vs 44.7%, P＜0.05) and lower ICU mortality rate (18.7% vs 38.3%, P＜0.05) than other patients. Compliance with the 24-hour bundle was obtained in 71 (60.7%) of 117 eligible patients. Patients complied with the 24-hour sepsis bundle had a lower 28-day and ICU mortality rate than those who were noncompliant (19.7% vs 41.3%, 15.5% vs34.8%, both P＜0.05). Conclusion Correct application of the sepsis bundles was associated with reduced mortality and length of ICU stay.