Intrahepatic Glissonian approach for mesohepatectomy in the management of primary hepatic tumors HU Ji-xiong，DAI Wei-dong，MIAO Xiong-ying，et al. Department of Hepatobiliary Surgery, the Second Xiangya Hospital of Central South University, Changsha 410011, China Corresponding author：DAI Wei-dong，E-mail:daiweidong@medmail.com.cn Abstract Objective To evalualte intrahepatic Glissonian approach for mesohepatectomy in the management of primary hepatic tumors. Methods The clinical data of 24 cirrhotic patients with primary liver tumor admitted from May 2005 to December 2007 at the Second Xiangya Hospital of Central South University were analyzed retrospectively. Results Mesohepatectomy was feasible with the proposed technique in all patients. No patients experienced massive bleeding during the operation. The estimated intraoperative mean amount of blood loss was 300mL (range 200 to 1200mL). The mean operating time was （258±60） minutes and only 2 patients required blood transfusion for 2U. Minor postoperative complications included bile leakage in 3 cases, subphrenic infection in 2 cases and resolved with conservative management. No hospital mortality occurred. Conclusion Intrahepatic Glissonian access for mesohepatectomy in cirrhotic patients is safe and effective. It may reduce intraoperative blood loss and the need for the pringle maneuver.