Diagnosis and treatment of idiopathic portal hypertension: a report of 28 cases MA Xiu-xian, XUE Ming-hui, SUN Yu-ling, et al. Department of General Surgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China Corresonding author: SUN Yu-ling, E-mail: ylsun@zzu.edu.cn Abstract Objective To investigate the clinical features, diagnosis and treatment of idiopathic portal hypertension. Methods The clinical data of 28 patients with idiopathic portal hypertension treated between 1987 and 2008 at the First Affiliated Hospital of Zhengzhou University were analyzed retrospectively. Results The operations included splenectomy and disconnection (14patients), the shunt from splenic vein to inferior vena cave and severed around cardiac blood vessels (8 patients), splenorenal shunt and gastric coronary vein suture (4 patients), splenectomy and the shunt from superior mesenteric vein to inferior vena cave by C-bridge ( 1 patient ), severed lower esophageal and around cardiac blood vessels ( 1 patient ) . Twenty-seven patients were followed up for six months to 17 years, who were in good condition. Hypersplenism, significant ascites, further bleeding and liver encephalopathy were disappeared. All liver function were normal. Esophageal varices was disappeared in 16 patients. Esophageal varices marked improvement in 9 patients. Esophageal varices did not change in 3 patients. Conclusion Cureing bleeding and prevention of recurrence of IPH are the key issue. The patients have no liver failure preferred surgical treatment which might be portal azygous disconnection or portosystemic shunt. The patients who can not tolerate surgery or were variceal bleeding after operation might be used endoscopic injection sclerotherapy or endoscopic ligation treatment.