Ultrasound-guided wire-localized surgical biopsies for nonpalpable breast lesions LI Yan-ping*, GAO Hong, WANG Hui-yu, et al. *Department of Breast Disease, Beijing Shijitan Hospital, Beijing 100038，China Corresponding author: LI Yan-ping, E-mail: liyanping112@yahoo.com.cn Abstract Objective To investigate the value and feasibility of wire-location surgical biopsies by ultrasound for non-palpable breast lesions. Methods Between March 2007 and December 2008, 57 women with 60 non-palpable breast lesions underwent surgery at Beijing Shijitan Hospital. Wire localization guided by ultrasound was performed before operation. Results All lesions founded by ultrasound were accurately localized and excised. Forteen (24.6%) cases were malignant and 16(28%) were ductal or lobular atypical hyperplasia by pathologic diagnosis. Conclusion Careful consideration should be taken for the cases of non-palpable breast lesions. Ultrasound-guided wire localization of breast lesions is useful in assisting surgical biopsy and worth extensive generalization.