Clinical research on regional intra-arterial infusion for the treatment of severe acute pancreatitis ZHOU Meng-tao*, ZHANG Qi-yu, WANG Chun-you, et al. *Department of Hepatobiliary & Pancreatic Surgery, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China Corresponding author: ZHANG Qi-yu, E-mail: qiyuz@126.com Abstract Objective To study the the rapeutic effect of regional arterial infusion（RAI）on severe acute pancreatitis (SAP) on early stage. Methods Forty-five cases of SAP were treated with RAI on early stage between August 1999 and June 2007 at the First Affiliated Hospital of Wenzhou Medical College. Then the state of illness, drugs infused, combined surgery and therapeutic effect were analyzed. Results ⑴The fatality rate was 4.4%. ⑵The incidence rate of complication was 35.6%(16/45).⑶The average length of hospital stay of total cases was 29.4 days; thereinto, the average length of hospital stay of the 33 cases with only RAI, 12 cases with RAI combined surgery was 23.1 days and 39.0 days, respectively. ⑷The average medical cost of total cases was 60.1 thousand yuan RMB; thereinto, the average medical cost of 33 cases with only RAI, 12 cases with RAI combined surgery was 44.3 thousand yuan RMB and 103.4 thousand yuan RMB, respectively. ⑸The incidence rate of secondary infection of total cases was 28.9%. Conclusion RAI can bring down the fatality rate, reduce the incidence rate of complications, shorten hospital stays, reduce medical cost. It is a synergistic non-operation therapeutic method of SAP.