Perioperative fluid resuscitation treatment for acute diffuse peritonitis QIN Huan-long，YANG Jun. Department of General Surgery, the Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233，China Corresponding author：QIN Huan-long，E-mail：hlqin@sjtu.edu.cn Abstract Acute diffuse peritonitis can cause abnormal distribution of body fluids. Inappropriate treatment may lead to essential organ damage, increase incidence of complications and mortality. In the paper, perioperative fluid distribution, liquid supplement strategy and the application of human serum albumin of the disease were described .