Application of modified end-to-side invagination pancreaticojejunostomy in pancreatoduodenectomy: an analysis of 21 cases ZHANG Bao-hua，YANG Jue，LI Nan，et al. Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China Corresponding author: ZHANG Bao-hua, E-mail: zhbh_1@tom.com Abstract Objective To investigate the improvement of pancreaticojejunostomy technique in pancreatoduodenectomy (PD), in order to decrease incidence of pancreatic leakage. Methods The clinical data of 21 cases of PD admitted between March 2006 to March 2008 at the Second Military Medical University was analyzed retrospectively. Intersection mattress suture was used for pancreaticojejunostomy that suture full-thickness of pancreas and seromuscular layer of jejunum at first layer. Results No pancreatic leakage occurred in the cases. Two cases of postoperative bleeding of gastrointestinal anastomosis occurred. No postoperative death occurred. Conclusion Intersection mattress suture is a safe and feasible method. The method is effective to decrease incidence of pancreatic leakage and it is valuable to be generalized and applied.