Effect of spleen on related diseases ZHANG Shu, ZHOU Rui, LI Zong-fang. Department of Surgery, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China Corresponding author: LI Zong-fang, E-mail: lzf2568@mail.xjtu.edu.cn Abstract As the largest immune organ, spleen is the important part of the regulation network between immune, nerve and endocrine system. The spleen would play an important role in pathogenesis and development of many diseases, because of the close relationship between spleen and other organs, which even could contribute to the important functions of other organs.