Therapeutic effects evaluation of liver transplantation for hepatic carcinoma and multi-factors analysis of the prognosis XIAO Liang, DING Guo-Shan, FU Hong, et al. Department of Liver Transplantation, the Second Affiliated Hospital, the Second Military Medical University, Shanghai 200003, China Corresponding author：DING Guo-Shan, E-mail：dingguoshan@medmail.com.cn Abstract Objective To evaluate the therapeutic effects of liver transplantation (LT) for primary hepatic carcinoma (PHC) and analyze the prognostic factors. Methods The clinical data of 234 patients underwent LT for hepatic carcinoma admitted between December 2001 and December 2006 at the Department of Liver Transplantation of the Second Affiliated Hospital of the Second Military Medical University were analyzed retrospectively. SPSS11.0 software was used for statistical analysis. The Kaplan-Meier method was used to evaluate the survival rates. Log-rank test and Cox regression model were used to analysis the single and multi-factors for the prognosis respectively．Results The follow-up time ranged from 1 to 56 months. The mortality was 36.3%. The recurrence rate was 29.9%. The 6-month, 1-, 2-, 3-and 4-year patient cumulative survival rates were 88.5%, 76.3%, 61.3%, 53.6% and 47.6%, respectively. The 6-month, 1, 2 and 3-year tumor-free survival rates were 80.1%, 70.6%, 60.4% and 52.3%, respectively. Univariate analysis showed that preoperative Child-pugh grade, serum AFP level, tumor type, tumor size, lymph node metastasis, macrovascular invasive, histological differentiation and TNM stage were prognostic factors of PHC after LT. Multivariate Cox regression analysis showed that the serum AFP level, tumor type, macrovascular invasive and histological differentiation were independent prognostic factors of PHC. Conclusion Liver transplantation is an effective treatment for PHC patients. Strict selection of recipients benefits long term posttransplant survival.