Comparison of clinicopathological features, surgical interventions and prognostic factors of resectable gastric cancer of different locations CAI Shi-rong, WU Hui, HE Yu-long, et al. Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China Corresponding author: HE Yu-long, E-mail: ylh@medmail.com.cn Abstract Objective To compare the clinicopathological features, surgical interventions and prognostic factors of resectable gastric cancer (GC) of different locations. Methods According to the lesion location, 356 cases of GC admitted between August 1999 and March 2006 at Gastric Cancer Center of Sun Yat-sen University were divided into 3 groups: upper tumor (U, 96 cases), middle tumor (M, 93cases) and lower tumor (L, 167cases). Their clinicopathological features, surgical interventions and prognostic factors were compared. Results There had no significant difference in tumor diameter, serosal infiltration (macroscopic observation), number of positive lymph nodes, TNM staging, histologic type, preoperative level of CEA among the three groups (P>0.05). The mean survival time in U, M, L was 49.0, 70.1, 70.9 months respectively. The prognosis of U was poorer than those of the other two groups. The independent prognostic factors of all cases included pTNM staging, Borrmann type, extent of lymphadenectomy. The pTNM staging and extent of lymphadenectomy were independent prognostic factors in U and L, while pTNM staging, Borrmann type in M. Conclusion The clinicopathological features and prognostic factors of resectable gastric cancer of different location are different. So gastric cancer of different locations should be treated with different surgical interventions.