Laparoscopic 180°anterior fundoplication for gastroesophageal refulx disease QIN Ming-fang，SUN Xiang-yu. Department of Mini-invasive Surgery, Tianjin Nankai Hospital, Tianjin 300100,China Corresponding author: QIN Ming-fang, E-mail: XiangYu Sun2007@Yahoo.cn Abstract Objective To investigate the reliability and effect of laparoscopic 180°anterior fundoplication for gastroesophageal refulx disease. Methods From January 2005 to April 2008, 54 cases of gastroesophageal refulx disease were treated by laparoscopic 180°anterior fundoplication. All the cases were followed up for 3 to 25 months. Results All the cases were treated by laparoscopic 180°anterior fundoplication. Laparoscopic 180°anterior fundoplication was found to provide better control of reflux related symptom. The postoperative esophageal manmometry increased from (6.7±1.3)mmHg to (19.1±3.4)mmHg（P1＜0.01） after 6 months, to (21.6±1.8 )mmHg （P2＜0.01） after 1 year. The DeMeester score of 24h pH monitor declined from 97.2±2.7 to 6.4±2.2 （P1＜0.01） after 6 months, to 6.7±2.3 （P2＜0.01） after 1 year. No postoperative complications occurred. There was no conversion to open operation and death. Conclusion Laparoscopic 180°anterior fundoplication offers the same effect as Nissen and Toupet of a high and durable level of disease control, moreover with few side effect.