Effect of early continuous highvolume hemofiltration on severe acute pancreatitis with acute lung injuryTONG Zhihui，LI Weiqin,YU Wenkui，et al．Research Institute of General Surgery,Nanjing General Hospital of Nanjing Command of PLA,Nanjing 210002，China Corresponding author：LI Weiqin，Email：liweiqin@jlonline.com AbstractObjectiveTo investigate the effect of early continuous highvolume hemofiltration (HVHF) on lung function in patients with severe acute pancreatitis.MethodsBased on the method of prospective,randomized and controlled clinical trial,55 patients suffered SAP with acute lung injury between January 2006 and December 2007 at Nanjing General Hospital of Nanjing Command of PLA were divided into control group and HVHF group.The oxygenation index,the morbility of ALI/ARDS and the case and time of mechanical ventilation (MV) between two groups were compared.Results（1）In HVHF group,the oxygenation indexes on the 3rd,10th day after admission were improved greater than those on the admission（P<005）.Meanwhile,in control group,the oxygenation index only on the 10d after admission was improved greater than that on the admission（P<005）.And the oxygenation indexes of 3d,10d after admission in HVHF group were improved greater than those in control group（P<005）.（2） In HVHF group,the morbility of ALI/ARDS on the 10th day after admission was lower than that on the admission（P<005）,but the same result was not seen in control group（P＞005）.And the morbility of ALI/ARDS on the 10d after admission in HVHF group was lower than that in control group（P<005）.（3）There were no significant difference between the two groups of the patients treated with MV（P＞005）.But the duration time of MV in HVHF group was shorter than that in control group（P<0.05）.ConclusionEarly continuous highvolume hemofiltration can improve the function of lung in SAP,and is an important adjunctive therapy.