Objective:To evaluate the feasibility and clinical outcome of the infusion catheterdirected thrombolysis for actue lower extremity ischemia. Methods:The clinical data of 8 cases of actue lower extremity ischemia treated with the urokinase infusion catheterdirected thrombolysis from August 2004 to April 2006 at the General Hospital of PLA were analyzed retrospectively.The infusion catheterdirected thrombolysis included accelerated thrombolysis with 250 000 to 500 000 IU of urokinase and the following infusion thrombolysis with 500 000 to 1 million U of urokinase.Adjunct angioplasty or stents implantation were pefromed after the infusion catheterdirected thrombolysis. Results:Eight limbs were saved. Initial success was 88% (7/8) in the eight cases,one distal artery thrombus during the infusion thrombolysis necessitated belowknee operative thromboembolectomy.The followup period ranges from 4 to 20 months,the cumulative patency was 75%(6/8). Conclusion:In patients with severe acute ischemia,transcatheter revascularization is a viable treatment option when strategies for reperfusion establish both inflow and microcirculatory outflow.