Objective:To explore the effectivity and safety of minimally invasive targeting ArgonHelium cryoablation in the treatment of hepatic carcinoma. Methods:Ultrasoundguided ArgonHelium targeting cryoablation using the CryoHit system with 1.47mm fine probe was performed percutaneously in 26 cases of primary hepatic carcinoma,15 cases of recurrent hepatic carcinoma and 13 cases of metastatic carcinoma with a total of 105 foci between June 2006 and June 2007 in the First People’s Hospital of Foshan.Serum tumor markers were detected and tumor necrosis was evaluated by ultrasonography,CT scan or MRI every 3 to 6 months.Survival rate was analyzed with KaplanMeier method. Results:One-year cumulative survival rates of primary,recurrent and metastatic hepatic carcinoma were 81.82%,46.22% and 80.21% respectively.Tumor foci diminished in different degrees or even disappeared when performed ultrasonography,CT scan or MRI after the procedures.Tumor complete necrosis rate could reach 96.2% to the foci less than 3cm,and they were 90.6% to the foci between 3cm to 5cm in size and 28.6% to the foci larger than 5cm.No complications such as bleeding or bile leakage were found. Conclusion:Ultrasoundguided targeting treatment of hepatic carcinoma with ArgonHelium cryoablation using fineprobe CryoHit system is a new,safe and effective procedure coming after radiofrequency and microwave ablation,although its longterm curative effects needs longterm follow-up survey.