Objective:To study the category of anticoagulant during the treatment of continuous blood purification in surgical severe sepsis patients and research the influence of the operation and infection on the effect of CBP. Methods:All severe sepsis patients who underwent CBP in the SICU of the First Affiliated Hospital of Sun Yet-sea University,from January 2006 to December 2007,were analysed retrospectively. Results:A total of 52 patients were included (42 males and 10 females) with the age of 60.8±16.0 years,and the time of CBP was 13.5±29.4 days.Eleven cases (21.15%) were anticoagulated with low molecular weight heparin,13 cases (25.00%) with heparin in vitro,19 cases (32.69%) completed the CBP without anticoagulant.The bleeding associated with anticoagulation was not observed.The impact of anticoagulation, operation and infection on the curative effect of CBP wasn't different significantly. Conclusion:CBP is a important therapy for surgical severe sepsis patients. The modality of anticoagulation should be individualization in the process of CBP.