Objective:To summarize the experience of the diagnosis and treatment of thyroid Hürthle cell tumor. Methods:The clinical data of 15 cases of Hürthle cell tumor of thyroid gland admitted between 2002 and 2005 in the Affiliated ZhongDa Hospital of Southeast University were analyzed retrospectively. Results:Among 15 cases of Hürthle cell tumor of thyroid gland,14 cases were female.The most common symptom was solitary thyroid mass.The thyroid function test was normal.Untrasonography and ECT couldn't make a definite diagnosis.Hürthle cells were found by the fine needle aspiration cytology examination.Frozen section could give a definite diagnosis during operation.Thirteen cases were benign tumor.Among them,8 cases were performed total lobectomy and isthmusectomy,and 2 cases complicated with thyroid papillary tumor were performed lobectomy.Radical resection were performed for 2 cases of malignant tumor.There were no recurrence during followup peroid. Conclusion:It is important to be familiar with the entity.Frozen section analysis should be required during operation.Choosing appropriate resection method can get a good prognosis.