Objective:To investigate the surgical methods of retroperitioneal tumor and major invaded blood vessel reconstruction. Methods:The clinical data of 86 cases performed retroperitioneal tumor resection complicated with invaded blood vessel reconstruction between July 1994 and June 2007 were analyzed retrospectively. Results:Among all the cases,81 cases were followed up with the period from 1 to 157 months (mean 6.8 years).Among 81 cases of prosthetic replacement,4 cases occurred prosthesis thromboembolism.One case of left arteria iliaca prosthesis occurred thromboembolism and left lower extremity occurred gangrene.The left articulatio coxae was disengaged.Three cases of vena iliaca prosthesis occurred thromboembolism in the postoperative 7 to 12 months,and the extremities swelled slightly.Seventyfour cases,61 cases and 39 cases were survived for more than 1 year,3 years and 5 years respectively.Eleven cases occurred tumor recurrence and be resected again during follow-up peroid. Conclusion:It is safe for retroperitioneal tumor resection complicated with invaded blood vessel reconstruction,which can improve resection effect,reduce recurrence rate and prolong the survival time.