Objective:To investigate the indication and method of gastrointestinal stromal tumor (GIST) complicated with multivisceral resection. Methods:The clinical data of 22 cases of GIST complicated with multivisceral resection between 1994 and 2005 in the Cancer Hospital of Fudan University were analyzed retrospectively. Results:The types of multivisceral operation included splenectomy (n=8),coloectomy (n=6),nepherectomy (n=5),partial hepatectomy (n=1),duodenectomy (n=1),oophorectomy (n=1),pancreatectomy (n=3),and adrenalectomy (n=1).Three cases were performed two adjacent organs resection, and 2 cases were performed 3 adjacent organs resection. None of lymph node metastasis was found in 7 cases with lymph node dissection with gastric stromal tumor (n=5) and small intestinal stromal tumor (n=2).The involved organs comfirmed by the pathology diagnosis included kidney (n=2),spleen (n=2),pancreas (n=2),mesentery (n=1) and omentum (n=1).There was no postoperative mortality in the series.Among followed up patients, 9 were survival and 5 cases were died from the tumor recurrence or metastasis. Conclusion:For the cases of GIST invading the adjacent organs,multivisceral resection could be benefit.Meanwhile,the operation indications are very important.Target drug combined with surgery may be a better method for the treatment of GIST.