Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor of the digestive tract, and surgical resection is the preferred treatment method. Laparoscopic and endoscopic cooperative surgery (LECS), combine the respective advantages of laparoscopy and endoscopy to achieve precise localization, complete resection, functional preservation, and minimally invasive treatment of GIST. In recent years, LECS has developed into various surgical techniques with different indications and advantages in clinical application. This article systematically summarizes the main surgical techniques, clinical application selection strategies, and research progress of LECS for the treatment of GIST. Combined with relevant guidelines and clinical practice, it also summarizes the technical points and difficulties in the implementation of LECS, aiming to further promote LECS and provide references for clinical practice.