PDF(1284 KB)
Research progress on artificial intelligence-empowered liquid biopsy for early detection and screening of hepatocellular carcinoma
CUI Yu-han, DU Zu-chao, WANG Ming-da, LI Chao, GU Li-hui, XU Jia-hao, YANG Tian
Chinese Journal of Practical Surgery ›› 2026, Vol. 46 ›› Issue (4) : 532-537.
PDF(1284 KB)
PDF(1284 KB)
Research progress on artificial intelligence-empowered liquid biopsy for early detection and screening of hepatocellular carcinoma
Recently, liquid biopsy and artificial intelligence (AI) technology offer promising early HCC detection opportunities. Liquid biopsy can provide non-invasive early molecular events from circulating tumour DNA mutations, methylation alterations and fragmentomic features, circulating tumour cells or extracellular vesicles. AI technologies such as machine learning and deep learning algorithm can overcome technical issues such as low-abundance signals and background noises for improved diagnostic performance. Building multimodal analytic models using liquid biopsies and clinical protein biomarkers, radiomics and pathomics features can improve model performance, which has substantial potential for clinical application. However, several barriers still impede clinical translation including poor technical standardization, low-interpretability of algorithms, poor external validation, and high implementation costs.
hepatocellular carcinoma / liquid biopsy / artificial intelligence / circulating tumour DNA / early detection of cancer
| [1] |
|
| [2] |
|
| [3] |
|
| [4] |
|
| [5] |
|
| [6] |
|
| [7] |
|
| [8] |
|
| [9] |
|
| [10] |
|
| [11] |
|
| [12] |
|
| [13] |
|
| [14] |
|
| [15] |
|
| [16] |
|
| [17] |
|
| [18] |
|
| [19] |
|
| [20] |
|
| [21] |
|
| [22] |
|
| [23] |
|
| [24] |
|
| [25] |
|
| [26] |
|
| [27] |
|
| [28] |
|
| [29] |
|
| [30] |
|
| [31] |
|
| [32] |
|
| [33] |
|
| [34] |
|
| [35] |
|
| [36] |
|
| [37] |
|
| [38] |
|
| [39] |
|
| [40] |
|
| [41] |
王昊, 赵鹏飞, 吕晗, 等. 数智化时代的医学影像学推动普通外科高质量发展[J]. 中国实用外科杂志, 2026, 46(1): 11-14. DOI:10.19538/j.cjps.issn1005-2208.2026.01.03.
|
| [42] |
|
| [43] |
|
| [44] |
|
| [45] |
|
| [46] |
|
| [47] |
|
| [48] |
|
| [49] |
|
| [50] |
|
| [51] |
|
| [52] |
|
| [53] |
|
| [54] |
|
| [55] |
|
| [56] |
|
| [57] |
|
| [58] |
|
| [59] |
|
| [60] |
|
| [61] |
|
| [62] |
|
| [63] |
|
| [64] |
|
| [65] |
|
利益冲突声明 所有作者均声明不存在利益冲突
/
| 〈 |
|
〉 |