This article provides a systematic interpretation of the “SAGES-AHPBA 2025 surgical management guidelines for bile duct injury after cholecystectomy”, jointly issued by the Society of American Gastrointestinal and Endoscopic Surgeons and the American Hepato-Pancreato-Biliary Association. The guidelines focus on definitive repair strategies for bile duct injuries following cholecystectomy. Utilizing the GRADE methodological framework, the guidelines address four key clinical questions, including timing of repair, treatment modality, surgical approach and anastomotic technique. All recommendations are “conditional”, supported by evidence of “low” or “very low” quality, reflecting the current lack of high-quality randomized controlled trials in this field. The guidelines emphasize multidisciplinary collaboration, individualized treatment, patient-centered care, and consideration of resource disparities and health equity. Overall, this guideline offers a structured, flexible, and practical decision-making framework based on the best available evidence and expert consensus.