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Surgical strategies and key technical points for complex hepatic hemangioma
DAI Chao-liu, JIA Chang-jun, ZHAO Yang, YAN Long
Chinese Journal of Practical Surgery ›› 2026, Vol. 46 ›› Issue (3) : 311-316.
PDF(6677 KB)
PDF(6677 KB)
Surgical strategies and key technical points for complex hepatic hemangioma
Complex hepatic hemangioma is a challenging procedure in hepatic surgery, often associated with high surgical risks and great technical difficulties due to its massive size and its adjacency to or encasement of important vascular and biliary structures in the hepatic hilar region. How to achieve safe resection under the premise of effectively controlling intraoperative bleeding and maximally preserving liver function is a core issue in clinical practice. For complex hepatic hemangiomas, surgical indications must be strictly grasped, adhering to the principle of “no treatment for asymptomatic cases; observation for non-enlarging tumors”. Treatment decisions should be based on clear clinical symptoms and exclude the influence of adjacent organ diseases. Meanwhile, refined evaluation by a multidisciplinary team (MDT) is emphasized. In particular, preoperative three-dimensional computed tomography (3D-CT) reconstruction and magnetic resonance cholangiopancreatography (MRCP) should be utilized to clarify the spatial relationship between the tumor and the hilar structures as well as the venous system, and to calculate the residual liver volume, thereby formulating individualized surgical plans. Hepatic inflow occlusion techniques (such as the Pringle maneuver) can effectively reduce intraoperative bleeding and shrink the tumor, thereby increasing the operating space. Hilar plate-related techniques are helpful in protecting biliary structures during the detachment and lowering of the hilar plate. In addition, anatomical dissection following the concept of Laennec’s capsule and the application of liver hanging maneuver when necessary, can simplify the operation and reduce the risk of venous injury. Regarding the selection of surgical procedures, the individualized principle of “enucleation as the first choice, resection when necessary” should be followed, and flexibly applied according to the anatomical characteristics of the tumor. In terms of perioperative management, the application of low central venous pressure (LCVP) technique and autologous blood transfusion is crucial for reducing wound bleeding and the risk of allogeneic blood transfusion. Postoperatively, close monitoring of hemodynamic stability, liver function, and coagulation function is required, along with active prevention and intervention of complications such as bleeding, biliary leakage, and infection. Refined preoperative evaluation, clear surgical strategies, combined with a profound understanding of liver anatomy and related membranous structure techniques, are the keys to achieving safe resection of complex hepatic hemangiomas and reducing complications.
hepatic hemangioma / hepatic hilar region / hilar plate / fascial anatomy / hepatic inflow occlusion
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国际肝胆胰协会中国分会肝血管瘤专业委员会. 肝血管瘤诊断和治疗多学科专家共识(2019版)[J]. 中国实用外科杂志, 2019, 39(8):761-765.DOI:10.19538/j.cjps.issn1005-2208.2019.08.01.
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This study aims to systematically evaluate the efficacy and safety of different bleomycin administration routes for treating GHHs, with a subgroup analysis comparing Transarterial chemoembolization (TACE) and percutaneous sclerotherapy (PS).A systematic literature search was conducted in MEDLINE, Scopus, and Web of Science from inception through May 6, 2025. Studies included reporting clinical and radiological outcomes after PS and TACE for GHHs (≥ 4 cm). Primary outcomes included technical success (complete and accurate application as predetermined in the study protocol), safety outcomes, clinical (symptom relief without additional intervention), and radiological success (≥ 50% size reduction and/or lack of enhancement on follow-up imaging). The outcomes were analyzed using a random-effects meta-analysis 106 1586.A total of 17 studies, including 1692 patients (1586 treated with TACE and 106 with PS) and 1825 GHHs, were included. Among these, 13 studies assessed TACE, and four studies evaluated PS. The overall technical success rate was 100%, with pooled clinical and radiological success rates of 96.93% and 81.75%, respectively. In subgroup analyses, both TACE and PS achieved 100% technical success. TACE showed slightly higher clinical success, at 99.9%, compared to PS at 89.73%, although the difference was not statistically significant (p = 0.15). Radiological success was comparable (TACE: 81.9%, PS: 81.29%). Major complications were rare (0.27%, 95% CI: 0-0.55%). No significant differences were observed in major complication rates (TACE: 0.26%, PS: 0.85%, p = 0.67), total complications (p = 0.48), or procedure-related morbidity.Both TACE and PS are effective treatments for GHHs, with PS showing a lower systemic complication rate.© 2025. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).
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To evaluate the safety and effectiveness of image-guided therapies-including transarterial chemoembolization (TACE), radiofrequency (RF) ablation, microwave ablation, and percutaneous sclerotherapy-for the treatment of giant hepatic hemangiomas (GHHs).A comprehensive search was performed across PubMed, Scopus, and Web of Science, including studies with ≥5 patients that reported image-guided treatment of GHHs. Primary outcomes included technical success, adverse events (AEs; classified according to the Society of Interventional Radiology [SIR] system), clinical success (symptom relief without additional intervention), and radiologic success (≥50% size reduction and/or lack of enhancement on follow-up imaging). A subgroup analysis was performed for GHHs of ≥10 cm. Outcomes were analyzed using a random-effect meta-analysis.Twenty-eight studies (2,617 patients; 32.5% men; mean age, 46.1 years [SD ± 3.2]) with 2,996 GHHs, ranging from 4 to 30 cm, were included. Of these, 22 were noncomparative, and 6 compared either 2 image-guided therapies or surgery, reporting outcomes for TACE (n = 13), RF ablation (n = 7), microwave ablation (n = 6), and percutaneous sclerotherapy (n = 4). The pooled technical success rate was 99.9%. Grade 2-4 AEs occurred in 1.64%, with TACE having the lowest rate (0.2%) and RF ablation the highest (2.1%). Clinical success at final follow-up was 99.9%, while radiological success was 85.7%. Grade 2-4 AEs were significantly higher in the subanalysis of GHHs of ≥10 cm (10.6%; P <.001), despite similar technical success and radiological and clinical outcomes.Image-guided therapies are safe and effective for GHHs, achieving high technical, clinical, and radiological success with minimal Grade 2-4 AEs. However, for GHHs ≥10 cm, AE rates were higher.Copyright © 2025 SIR. Published by Elsevier Inc. All rights reserved.
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肝脏良性肿瘤(benign liver tumors,BLTs)除肝血管瘤外,较为少见,但一直是临床肝胆外科专家争议较多的问题。近年来,随着影像学技术的发展,肝脏良性病变的检出率不断提高,也积累了较为丰富的诊治经验,要切实提高对BLTs的规范化诊治水平,则还需做大量的探索与实践。
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Liver resection (LR) and enucleation (EN) are the main surgical treatment for giant hepatic hemangioma (HH), but how to choose the type of surgery is still controversial. This study aimed to explore the efficacy and the factors affecting the choice of open procedure for HH.The data for patients with pathologically confirmed HH who underwent open surgery from April 2014 to August 2020 were analyzed retrospectively. Univariate and multivariate analyses with logistic regression were performed to disclose the factors associated with the choice of EN or LR. Propensity score matching (PSM) analysis was used to compare the efficacy of the two procedures.A total of 163 and 110 patients were enrolled in the EN and LR groups. Following 1:1 matching by PSM analysis, 66 patients were selected from each group. Centrally located lesions (OR: 0.131, 95% CI 0.070-0.244), tumors size > 12.1 cm (OR: 0.226, 95% CI 0.116-0.439) and multiple tumors (OR: 1.860, 95% CI 1.003-3.449) were independent factors affecting the choice of EN. There was no significant difference in the median operation time (156 vs. 195 min, P = 0.156), median blood loss (200 vs. 220 ml, P = 0.423), blood transfusion rate (33.3% vs. 33.3%, P = 1.000), mean postoperative feeding (3.1 vs. 3.3 d, P = 0.460), mean postoperative hospital stay (9.5 vs. 9.0 d, P = 0.206), or the major complication rates between the two groups.Peripherally located lesions, tumors size ≤ 12.1 cm and multiple tumors were more inclined to receive EN. There was no significant difference in the efficacy of EN or LR.
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