Poorly differentiated thyroid carcinoma (PDTC) is a rare pathological subtype of thyroid carcinoma whose morphological characteristics and biological behavior are intermediate between differentiated thyroid carcinoma and anaplastic carcinoma. PDTC is highly invasive, and is prone to recurrence and metastasis. Its diagnostic criteria are not yet unified, and the“Turin Criteria”are widely adopted internationally. Extrathyroidal invasion and distant metastasis are independent risk factors affecting the prognosis of PDTC. Currently, there is no consensus on the treatment strategies for PDTC. Surgery is the primary treatment modality for PDTC, while adjuvant therapies such as radioactive iodine therapy, external beam radiation therapy, and targeted therapy remain controversial.
Key words
poorly differentiated thyroid carcinoma /
diagnostic criteria /
extrathyroidal invasion /
distant metastasis /
molecular testing /
surgical treatment /
radioactive iodine therapy /
targeted therapy
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