To summarize the clinical experience of robotic-assisted precise hepatectomy, explore the surgical techniques and standardized operational procedures based on precise anatomy, and analyze the efficacy of robotic-assisted hepatectomy. Methods    A retrospective analysis was performed on the clinical data of 600 patients with hepatic space-occupying lesions who underwent robotic-assisted precise hepatectomy at the First Affiliated Hospital of Harbin Medical University from July 2021 to July 2025. Clinical data included operative time, intraoperative blood loss, intraoperative blood transfusion volume, conversion to open surgery, postoperative liver function, postoperative drainage tube removal time, postoperative complications, postoperative hospital stay, and postoperative hospital costs. Additionally, the application of precise anatomy in robotic-assisted precise hepatectomy was summarized. Results    All patients included 206 cases of malignant tumors and 394 cases of benign diseases. For patients with benign diseases, the operative time was 130.0 (94.0, 165.0) min, and the intraoperative blood loss was 50.0 (50.0, 100.0) mL. For patients with malignant liver tumors, the operative time was 150.0 (100.0, 195.0) min, and the intraoperative blood loss was 80.0 (50.0, 120.0) mL. None of the patients required conversion to open surgery, and postoperative liver function recovered well. For patients with benign liver tumors, the postoperative drainage tube removal time was 7.0 (6.0, 8.0) d, the postoperative hospital stay was 8.0 (7.0, 9.0) d, and the hospital cost was 73 590.0 (70 900.3, 76 445.5) yuan. For patients with malignant liver tumors, the postoperative drainage tube removal time was 8.0 (6.0, 9.0) d, the postoperative hospital stay was 9.0 (8.0, 10.0) d, and the hospital cost was 79 657.0 (77 242.5, 82 531.5) yuan. The incidence of Clavien-Dindo grade Ⅲ or higher complications in all patients was 1.5%, including 2 cases of postoperative bleeding, 1 case of biliary leakage, and 6 cases of hypoalbuminemia. There were no perioperative deaths, and the mortality rate within 90 d postoperatively was 0. Conclusion    Under the premise of precise anatomy, standardized surgical procedures for robotic-assisted hepatectomy can effectively ensure surgical safety and efficacy, with advantages such as high precision, minimal invasiveness, and few complications.