关键词: 胰腺癌, 免疫治疗, 肿瘤疫苗, 过继细胞治疗, 溶瘤病毒

Abstract: Pancreatic cancer presents as an aggressive malignancy with a dismal prognosis and limited therapeutic modalities. It is urgent to develop novel treatment strategies to prolong patient survival. Immunotherapy has demonstrated promising clinical efficacy in various solid tumors in recent years, while its efficacy within the realm of pancreatic cancer treatment is limited. The dense matrix of pancreatic cancer and highly immunosuppressive tumor microenvironment (TME) may be the key factors affecting the effect of immunotherapy. Reversing the immunosuppressive state of pancreatic cancer and remodeling TME are expected to improve the efficacy of immunotherapy. The combination of immune checkpoint inhibitors with chemotherapy or radiotherapy has yielded clinical outcomes to some extent, but it remains in the exploration stages. Concurrently, innovative immunotherapeutic strategies such as adoptive cell therapy, oncolytic viruses, and tumor vaccines have shown potential, yet their application is hindered by various intrinsic limitations. An overall understanding of the complex tumor ecosystem of pancreatic cancer is key to improving the effectiveness of immunotherapy. The future landscape of immunotherapy for pancreatic cancer is anticipated to integrate innovative approaches with a comprehensive and personalized precision medicine paradigm.

Key words: pancreatic cancer, immunotherapy, tumor vaccine, adoptive cell therapy, oncolytic virus