关键词: D-聚体, 静脉血栓栓塞症

Abstract:

The diagnosis value of  D-dimer in acute venous thromboembolism        ZHAO Yu，ZHANG Mao. Department of Vascular Surgery， the First Hospital Affiliated Chongqing Medical University , Chongqing 400016, China
Corresponding author ：ZHAO Yu，E-mail：zhaoyu1@medmail.com.cn
Abstract    D-dimer is the end products derived from cross-linked fibrin acted on by plasmin. As long as there is activated intravascular thrombosis and fibrinolytic activity in the body, the lever of D-dimer would rise. D-dimer negative can exclude diagnosis of acute venous thromboembolism (VTE)；D-dimer positive combined with clinical manifestations can diagnose acute VTE in special cases. In addition, monitoring D-dimer can reflect the effects of anticoagulant and thrombolytic drugs treating acute VTE，and can evaluating the risk factor of recurrence and prognosis of VTE. The lever of D-dimer in old people, patients with cancer, pregnant women and other specific groups are generally high,  therefore, cutoff value of D-dimer for diagnosis VTE should be appropriately adjusted in order to increase diagnostic efficiency of D-dimer.

Key words: D-dimer, venous thromboembolism