D-二聚体是交联纤维蛋白经纤溶酶作用后的终末产物。只要机体血管内有活化的血栓形成及纤维溶解活动，D-二聚体就会升高。D-二聚体检测阴性可用于急性静脉血栓栓塞症（VTE）的排除诊断；特殊情况下，D-二聚体阳性结合临床表现可用于急性VTE的诊断。此外，D-二聚体的监测还可反映急性VTE药物抗凝溶栓治疗的效果以及评价VTE复发的危险程度及预后。老年、肿瘤、孕妇等特定人群的D-二聚体普遍偏高，VTE诊断的D-聚体截断值应作适当的调整，以调高D-聚体的诊断效率。

The diagnosis value of  D-dimer in acute venous thromboembolism        ZHAO Yu，ZHANG Mao. Department of Vascular Surgery， the First Hospital Affiliated Chongqing Medical University , Chongqing 400016, China
Corresponding author ：ZHAO Yu，E-mail：zhaoyu1@medmail.com.cn
Abstract    D-dimer is the end products derived from cross-linked fibrin acted on by plasmin. As long as there is activated intravascular thrombosis and fibrinolytic activity in the body, the lever of D-dimer would rise. D-dimer negative can exclude diagnosis of acute venous thromboembolism (VTE)；D-dimer positive combined with clinical manifestations can diagnose acute VTE in special cases. In addition, monitoring D-dimer can reflect the effects of anticoagulant and thrombolytic drugs treating acute VTE，and can evaluating the risk factor of recurrence and prognosis of VTE. The lever of D-dimer in old people, patients with cancer, pregnant women and other specific groups are generally high,  therefore, cutoff value of D-dimer for diagnosis VTE should be appropriately adjusted in order to increase diagnostic efficiency of D-dimer.