关键词: 肠外营养, 肠外营养相关性肝损伤, 胆汁淤积, 短肠综合征

Abstract: Mechanism and prevention of parenteral nutrition-associated liver injury        XU Xuan, CHEN Wei. Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
Corresponding author: CHEN Wei, E-mail: txchenwei@sina.com
Abstract    Parenteral nutrition-associated liver disease (PNALD) is a serious metabolic complication associated with continuous parenteral nutrition (PN) and a common complication. Its pathophysiological changes are mainly manifested as cholestasis and hepatic fat infiltration, and clinically manifested as liver enzyme abnormalities, cholestasis, and jaundice, which can lead to irreversible damage of liver function and even liver failure and death in severe cases, and there is no early identification method. The mechanisms associated with PNALD are unknown and are currently thought to include cholestasis, the composition of parenteral nutrition, and gut-associated infections. The diagnosis of PNALD can be considered when other common causes of liver damage are excluded and there is a history of PN infusion. The principle of treatment for PNALD is to resume enteral nutrition as early as possible with the addition of hepatoprotective drugs.

Key words: parenteral nutrition, parenteral nutrition-associated liver disease, cholestasis, short bowel syndrome